Gas chromatographic determination of ibogaine in biological fluids

Abstract

Pharmacological studies of the alkaloid ibogaine showed that it has a stimulating action on the central nervous system; in small doses, it produces a light euphorizing effect, like morphine, and increase muscular and cerebral activity; at high doses, together with the central action, it produces apprehension, fear, a sense of inebriation and often hallucinations.
For these reasons, we have studied methods for the determination of this alkaloid in biological fluids.
Ibogaine is extracted from Thabernanthe iboga and is characterized by the following structure, in which an indolic group is present.

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