Effects of lysergic acid diethylamide (LSD 25), 2-bromolysergic acid diethylamide (BOL 148), bufotenine, mescaline, and ibogaine on the potentiation of hexobarbital hypnosis produced by serotonin and reserpine.

Abstract

Lysergic-acid-diethylamide (LSD), a potent serotonin-blocking agent on isolated organs, is shown here to enhance, rather than to block, the potentiating effect of serotonin on hexobarbital hypnosis in mice when given in the small dosage range (microgm./kgm. equivalent) that produces hallucinations in man.

A similar enhancing effect is also produced by small doses of other hallucinogens (bufotenine, mescaline and ibogaine) and also by small doses of brom-lysergic-acid-diethylamide (BOL), a lysergic acid derivative that does not produce mental changes in man when given orally but may do so when given by intravenous infusion together with large doses of serotonin.

The enhancing effect of small doses of LSD, BOL, bufotenine, mescaline and ibogaine does not extend to the reserpine-induced prolongation of hexobarbital hypnosis in mice; all these compounds, in large and small doses, block this effect of reserpine.

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