Assessment of Neurotoxicity from Potential Medications for Drug Abuse: Ibogaine Testing and Brain Imaging

Abstract

The resistance of drug abuse disorders to existing therapies underscores the need for new medications for treatment. Pharmacological actions of such drugs in the central nervous system (CNS) can be assessed using technologies developed in a variety of disciplines, ranging from anatomy and biochemistry through psychology and medical physics. The development of the hallucino- gen ibogaine as a potential therapeutic agent will serve to illustrate the approaches used to elucidate toxic effects in laboratory animals and the proposed assessment of analogous deficits in human subjects.

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