Room-temperature fluorescence and low-temperature phosphorescence excitation and emission spectra, phosphorescence lifetimes and/or fluorimetric and/or phosphorimetric analytical curves and limits of detection have been determined in methanol-water solution for nine hallucinogenic drugs, including lysergic acid diethylamide (LSD), lysergic acid, 2,5-dimethoxy-4-methylamphetamine (STP; DOM), mescaline and indole-type hallucinogens. Vibrational structure of phosphorescence bands, phosphorescence lifetimes and effect of pH on the phosphorescence spectra at 77°K are shown to be of value for the identification of these hallucinogens. Fluorimetric and phosphorimetric analytical curves are linear over large concentration ranges (102-104) concentration units. Detection limits are very low, between 1 and 23 ppb, according to the fluorescence and/or phosphorescence spectrum yield of the particular compound. The combined fluorimetric and phosphorimetric method is demonstrated to improve largely the sensitivity of previous analytical techniques used for the determination of hallucinogens.
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